DESIGN, SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLES CONTAINING INDOL- THIAZOLYL- THIAZOLIDINONE DERIVATIVES

Synthesis of new 1, 8-dioxo-octahydroxanthene derivatives containing 4-thiazolidinone moiety containing 4-thiazolidinone moiety

A series of novel 1, 8-dioxo-octahydroxanthene derivatives containing 4-thiazolidinone framework (4a-f) were synthesized through a four-step reaction starting from the reduction of nitro derivatives of 1, 8-dioxo-octahydroxanthenes. The resulting aminoxanthenes converted to thiourea derivatives via their reaction with methyl isothiocyanate. The final products were synthesized through the re...

Synthesis, Characterization and In Vitro Antimicrobial Activity of Some New 2,3-Disubstituted-4-Thiazolidinone and 2,3-Disubstituted-5- Methyl-4-Thiazolidinone Derivatives As a Biologically Active Scaffold

In recent years, there has been a rising interest in researching and finding new antimicrobial agents from various sources to fight against microbial infectious pathogens. Therefore, a greater attention has been paid to synthesize new molecules. In this regarding a straightforward two-step protocol for the synthesis of 2,3-disubstituted-4-thiazolidinone (4a-f) and 2,3disubstituted-5-methyl-4-th...

Synthesis of Some Nitrogen Functional Derivatives of 5-substituted-6-azauracil as Biologically Active Compounds

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds ...

Chemoenzymatic Synthesis of Biologically Relevant Heterocycles

Synthesis of novel, potentially biologically active dibenzosuberone derivatives.

Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3)....